Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.58 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.58 |
| ▸ | CTSS | P25774 | 3/20 | 0.55 |
| ▸ | PTPRA | P18433 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571465 | 0.93 | PTPN1 (0.65) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6572579 | 0.89 | PTPN1 (0.64) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6572625 | 0.89 | PTPN1 (0.67) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6572629 | 0.89 | PTPN1 (0.67) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6573532 | 0.89 | PTPN1 (0.60) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6571529 | 0.88 | PTPN1 (0.56) | PTPN1PTPN22PTPRAPSMB8PSMB9 | |
| SCHEMBL6575040 | 0.88 | PTPN1 (0.65) | PTPN1PTPN22CTSSPTPRAPPARA | |
| SCHEMBL6572831 | 0.88 | PTPN1 (0.64) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6572795 | 0.88 | PTPN1 (0.61) | PTPN1PTPN22CTSSPTPRACTSL | |
| SCHEMBL6575145 | 0.87 | PTPN1 (0.58) | PTPN1PTPN22CTSSPTPRAPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |