Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.43 |
| ▸ | PDE4A | P27815 | 8/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467226 | 0.84 | RECQL (0.53) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7420665 | 0.76 | PDE4B (0.48) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7420478 | 0.75 | PDE4B (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7420475 | 0.75 | PDE4B (0.47) | PDE4DPDE4BPDE4APDE4CEPHX2 | |
| SCHEMBL1157799 | 0.74 | POLB (0.55) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7940494 | 0.74 | RECQL (0.43) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7418284 | 0.73 | RECQL (0.47) | PDE4DPDE4BPDE4APDE4CRECQL | |
| SCHEMBL1157461 | 0.73 | POLB (0.54) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1157480 | 0.73 | PDE4A (0.57) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1157367 | 0.72 | PDE4A (0.62) | POLBPDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429843-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA Pharma AG (DE) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |