Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 9/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 9/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL6569138 | 0.95 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6569133 | 0.83 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6571776 | 0.81 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7247433 | 0.81 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8659617 | 0.80 | ABCC9 (0.46) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8656072 | 0.79 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7251787 | 0.79 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7247986 | 0.78 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8657172 | 0.78 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7253590 | 0.78 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |