SCHEMBL6571836

SCHEMBL6571836

CCCCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc(C(COC)C(=O)OCC)cc1

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 0.49
PPARA Q07869 10/20 0.47
PPARD Q03181 5/20 0.47
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5391253 0.86 L3MBTL1 (0.51) PPARGPPARAPPARDLMNA
SCHEMBL5206355 0.82 PPARG (0.57) PPARGPPARAPPARD
SCHEMBL5206352 0.82 PPARG (0.57) PPARGPPARAPPARD
SCHEMBL6572868 0.78 PPARA (0.70) PPARGPPARAPPARD
SCHEMBL5209812 0.77 PPARG (0.56) PPARGPPARAPPARD
SCHEMBL22281385 0.75 PPARG (0.67) PPARGPPARAPPARD
SCHEMBL5205091 0.74 PPARG (0.50) PPARGPPARAPPARDLMNA
SCHEMBL6933751 0.74 PPARG (0.64) PPARGPPARAPPARD
SCHEMBL14621664 0.74 PPARG (0.56) PPARGPPARAPPARD
SCHEMBL5208965 0.74 PPARD (0.57) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392637-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2004-03-03 EP disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 WO disclosed