Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375749 | 0.77 | KDM4E (0.41) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL6572287 | 0.72 | KDM4E (0.37) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL14181402 | 0.71 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL28477281 | 0.71 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL17285667 | 0.71 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL28466394 | 0.71 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL4760786 | 0.69 | KDM4E (0.38) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL10359470 | 0.69 | MTNR1A (0.41) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL8433355 | 0.69 | MTNR1A (0.41) | MTNR1AMTNR1BKDM4EMAPK1HIF1A | |
| SCHEMBL6573142 | 0.68 | KDM4E (0.46) | MTNR1AMTNR1BKDM4EMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056445-B1 | ORALLY ADMINISTRABLE IMMEDIATE-RELEASE AND PROLONGED-RELEASE GALENIC FORM COMPRISING AN ABSORPTION-PROMOTING AGENT AND USE OF THIS ABSORPTION-PROMOTING AGENT | MERCK PATENT GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |
| EP-1410791-A1 | Orally administrable galenic form comprising metformine and an absorption-promoting agent | MERCK PATENT GmbH (DE) | 2004-04-21 | — | — | EP | disclosed |
| US-6514524-B1 | Improved absorption of hydrophilic ingredients because of particular excipients; calcium 3-acetylamino-1-propane sulfonate (calcium acamprosate); polysorbates, fatty ethers or esters of PEG, polyglycolysed glycerides | MERCK PATENTGESELLSCHAFT MIT (DE) | 2003-02-04 | — | — | US | disclosed |
| US-6426087-B1 | GALENIC FORMS; SUSTAINED RELEASE | MERCK PATENT GESELLSCHAFT MIT (DE) | 2002-07-30 | — | — | US | disclosed |