SCHEMBL6572121

SCHEMBL6572121

COC(=O)C(c1ccc(OC)c(OC)c1)[N+](=O)[O-]

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.61
CYP2C19 P33261 1/20 0.61
LMNA P02545 1/20 0.49
TNF P01375 3/20 0.46
ACHE P22303 2/20 0.46
HTT P42858 1/20 0.43
HPGD P15428 1/20 0.43
ALOX5 P09917 1/20 0.43
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
KDM4E B2RXH2 1/20 0.42
POLB P06746 1/20 0.42
CTDSP1 Q9GZU7 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
PPARG P37231 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4099979 0.86 ACHE (0.54) ALDH1A1CYP2C19LMNATNFACHE
SCHEMBL3042994 0.78 CYP2C19 (0.52) ALDH1A1CYP2C19ACHECA1CA2
SCHEMBL5025140 0.77 CYP2C19 (0.55) ALDH1A1CYP2C19LMNAACHEHPGD
Bicarbonate SCHEMBL7262670 0.77 CYP2C19 (0.52) ALDH1A1CYP2C19LMNAACHEHPGD
SCHEMBL7616945 0.77 TSHR (0.46) ALDH1A1CYP2C19LMNACA1CA2
SCHEMBL2761650 0.76 KMT2A (0.56) ALDH1A1LMNA
SCHEMBL187421 0.76 ACHE (0.55) ALDH1A1CYP2C19LMNAACHEHPGD
SCHEMBL5022505 0.76 CYP2C19 (0.54) ALDH1A1CYP2C19ACHEHPGDCA1
SCHEMBL187420 0.76 ACHE (0.55) ALDH1A1CYP2C19LMNAACHEHPGD
SCHEMBL31083332 0.76 CYP2C19 (0.54) ALDH1A1CYP2C19ACHEHPGDCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775689-B9 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2004-09-15 EP disclosed
EP-0775689-B1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2003-09-03 EP disclosed
US-6057358-A POTASSIUM CHANNEL BLOCKING ANTIARRHYTHMIC DRUGS WITH LESS SIDE EFFECTS C&C RESEARCH LABS. (KR) 2000-05-02 US disclosed
EP-0775689-A1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RESEARCH LABS. (KR) 1997-05-28 EP disclosed