SCHEMBL6572228

SCHEMBL6572228

Cc1ccc2c(c1)c1cc3c(cc1n2-c1ccc(-c2ccc(N(c4ccccc4)c4ccccc4)cc2)cc1)c1cc(C)ccc1n3-c1ccc(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.38
KDM4E B2RXH2 4/20 0.35
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 4/20 0.35
GAA P10253 2/20 0.35
BCHE P06276 1/20 0.35
ACHE P22303 1/20 0.35
GFER P55789 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
HPGD P15428 2/20 0.34
HTT P42858 2/20 0.34
LMNA P02545 1/20 0.34
PGR P06401 1/20 0.34
RORA P35398 1/20 0.34
RORC P51449 1/20 0.34
RORB Q92753 1/20 0.34
POLB P06746 1/20 0.34
AKR1C4 P17516 1/20 0.34
AKR1C3 P42330 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7021752 0.99 APP (0.37) APPKDM4EATML3MBTL1MAPT
SCHEMBL17736383 0.97 APP (0.40) APPKDM4EATML3MBTL1MAPT
SCHEMBL12704960 0.97 APP (0.40) APPKDM4EATML3MBTL1MAPT
SCHEMBL6569159 0.96 APP (0.37) APPKDM4EATML3MBTL1MAPT
SCHEMBL12704847 0.96 APP (0.39) APPKDM4EATML3MBTL1MAPT
SCHEMBL13620174 0.96 APP (0.39) APPKDM4EATML3MBTL1MAPT
SCHEMBL1637358 0.96 APP (0.40) APPKDM4EATML3MBTL1MAPT
SCHEMBL16922599 0.94 NLRP3 (0.38) APPKDM4EATML3MBTL1MAPT
SCHEMBL20812929 0.94 NLRP3 (0.38) APPKDM4EATML3MBTL1MAPT
SCHEMBL15504027 0.94 NLRP3 (0.38) APPKDM4EATML3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0908787-B1 Indolocarbazole Photoconductors XEROX CORP (US) 2004-04-14 EP claimed
EP-0906948-B1 Electroluminescent devices XEROX CORP (US) 2003-02-12 EP claimed
EP-0908787-A2 Indolocarbazole Photoconductors Xerox Corporation (US) 1999-04-14 EP claimed
EP-0906948-A1 Electroluminescent devices Xerox Corporation (US) 1999-04-07 EP claimed
EP-0908787-B1 Indolocarbazole Photoconductors XEROX CORP (US) 2004-04-14 EP disclosed
EP-0908787-A2 Indolocarbazole Photoconductors Xerox Corporation (US) 1999-04-14 EP disclosed
EP-0906948-A1 Electroluminescent devices Xerox Corporation (US) 1999-04-07 EP disclosed