Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505488 | 0.81 | POLB (0.43) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL8209902 | 0.74 | HDAC8 (0.41) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL4679652 | 0.71 | POLB (0.58) | POLBGBA1SLC22A1PRCP | |
| SCHEMBL2001366 | 0.70 | GBA1 (0.52) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL8125961 | 0.70 | SLC22A1 (0.41) | POLBGBA1SLC22A1PRCPADRB2 | |
| SCHEMBL15229389 | 0.69 | GBA1 (0.47) | POLBGBA1 | |
| SCHEMBL17542064 | 0.68 | POLB (0.71) | POLBGBA1 | |
| Hydrochloric Acid SCHEMBL27721964 | 0.68 | POLB (0.50) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL17542062 | 0.68 | POLB (0.71) | POLBGBA1 | |
| SCHEMBL9579800 | 0.68 | POLB (0.42) | POLBGBA1SLC22A1PRCPHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395551-A2 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND SIMILAR DISEASES | Elan Pharmaceuticals, Inc. (US) | 2004-03-10 | — | — | EP | claimed |
| WO-2002098849-A2 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER’S DISEASE AND SIMILAR DISEASES | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1395551-A2 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND SIMILAR DISEASES | Elan Pharmaceuticals, Inc. (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002098849-A2 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER’S DISEASE AND SIMILAR DISEASES | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |