Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572638 | 0.81 | POLB (0.46) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL17047998 | 0.81 | POLB (0.42) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL12473022 | 0.70 | CYP2C19 (0.41) | POLBGBA1 | |
| SCHEMBL4679652 | 0.68 | POLB (0.58) | POLBGBA1SLC22A1PRCP | |
| SCHEMBL2001366 | 0.67 | GBA1 (0.52) | POLBGBA1SLC22A1PRCPHDAC8 | |
| SCHEMBL845572 | 0.67 | — | — | |
| SCHEMBL8125961 | 0.67 | SLC22A1 (0.41) | POLBGBA1SLC22A1PRCP | |
| SCHEMBL11634524 | 0.67 | CHRNB2 (0.64) | GBA1PRCPCHRNB2CHRNA4 | |
| SCHEMBL1200566 | 0.67 | GBA1 (0.42) | POLBGBA1 | |
| SCHEMBL17881913 | 0.67 | CHRNB2 (0.64) | GBA1PRCPCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807078-A1 | DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006042150-A1 | DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| US-4238488-A | ANTICOAGULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-09 | — | — | US | disclosed |
| US-3969468-A | 2-Amino-1,2,3,4-tetrahydronaphthalene derivatives | KYOWA HAKKO KOGYO CO., LTD. (JA) | 1976-07-13 | — | — | US | disclosed |
| US-3969468-A | 2-Amino-1,2,3,4-tetrahydronaphthalene derivatives | KYOWA HAKKO KOGYO CO., LTD. (JA) | 1976-07-13 | — | — | US | disclosed |