Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793617 | 1.00 | ADORA2A (0.56) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL6575255 | 0.90 | ADORA2A (0.58) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL6573057 | 0.89 | ADORA2A (0.69) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL6574065 | 0.87 | ADORA2A (0.59) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL13337623 | 0.81 | ADORA2A (0.72) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL13309344 | 0.81 | ADORA2A (0.72) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL5507625 | 0.81 | ADORA3 (0.62) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL5504161 | 0.81 | TSHR (0.52) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL12200089 | 0.81 | ADORA3 (0.69) | ADORA2AADORA2BADORA3ADORA1TSHR | |
| SCHEMBL7735031 | 0.81 | ADORA3 (0.69) | ADORA2AADORA2BADORA3ADORA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090019-B1 | ADENOSINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-09-29 | — | — | EP | disclosed |
| EP-1447407-A1 | Adenosine derivatives | GLAXO GROUP LIMITED (GB) | 2004-08-18 | — | — | EP | disclosed |
| US-6492348-B1 | Adenosine derivatives | SMITHKLINE BEECHAM CORPORATION | 2002-12-10 | — | — | US | disclosed |
| EP-1090019-A1 | ADENOSINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067262-A1 | ADENOSINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-29 | — | — | WO | disclosed |