Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.48 |
| ▸ | CHRNG | P07510 | 2/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.48 |
| ▸ | CHRND | Q07001 | 2/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572832 | 1.00 | SRC (0.55) | SRCGRIA1PTPN1FOLH1CHRNA1 | |
| SCHEMBL6574908 | 0.89 | PTPN1 (0.66) | GRIA1PTPN1FOLH1CHRNDCHRNB2 | |
| SCHEMBL6575538 | 0.87 | SRD5A2 (0.45) | SRCGRIA1PTPN1FOLH1ITGB3 | |
| SCHEMBL6573106 | 0.87 | GRIA1 (0.50) | GRIA1CHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL6572344 | 0.87 | PTPN1 (0.62) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL6571434 | 0.87 | PTPN1 (0.62) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL6573110 | 0.87 | GRIA1 (0.50) | GRIA1CHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL6571438 | 0.87 | PTPN1 (0.62) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL6575632 | 0.86 | KLKB1 (0.46) | PTPN1FOLH1 | |
| SCHEMBL6575066 | 0.86 | PTPN1 (0.61) | GRIA1PTPN1CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | claimed |
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |