Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571501 | 1.00 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL6571386 | 1.00 | P2RX7 (0.67) | P2RX7 | |
| Hydrochloric Acid SCHEMBL6573385 | 0.99 | P2RX7 (0.66) | P2RX7 | |
| Hydrochloric Acid SCHEMBL6572046 | 0.99 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL7459173 | 0.89 | P2RX7 (0.53) | P2RX7 | |
| SCHEMBL6572999 | 0.86 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL6572989 | 0.86 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL6573013 | 0.86 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL6571668 | 0.86 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL6572850 | 0.86 | P2RX7 (0.72) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720452-B2 | SUBSTITUTED BENZMIDE-N-METHYL ADMANATANE DERIVATIVES USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2004-04-13 | — | — | US | claimed |
| EP-1240132-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-04-07 | — | — | EP | claimed |
| US-6720452-B2 | SUBSTITUTED BENZMIDE-N-METHYL ADMANATANE DERIVATIVES USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2004-04-13 | — | — | US | disclosed |
| EP-1240132-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| EP-1240132-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001042194-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-14 | — | — | WO | disclosed |