SCHEMBL65730

SCHEMBL65730

N=C(N)c1ccc2[nH]c(Cc3nc4cc(C(=N)N)ccc4[nH]3)nc2c1

nearest known ligand 0.77

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F10 P00742 12/20 0.77
TPSAB1 Q15661 3/20 0.77
F2 P00734 3/20 0.77
PRSS1 P07477 2/20 0.77
PLG P00747 1/20 0.77
PLAU P00749 1/20 0.77
PRSS2 P07478 1/20 0.77
PRSS3 P35030 1/20 0.77
TPSD1 Q9BZJ3 1/20 0.75
TPSG1 Q9NRR2 1/20 0.75
F7 P08709 2/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4322200 0.98 TPSAB1 (0.78) F10TPSAB1F2PRSS1PLG
SCHEMBL6163820 0.93 F10 (0.85) F10TPSAB1F2PRSS1PLG
SCHEMBL7406105 0.93 F10 (0.68) F10TPSAB1F2PRSS1PLG
SCHEMBL7406681 0.93 F10 (0.68) F10TPSAB1F2PRSS1PLG
SCHEMBL7406863 0.92 F10 (0.76) F10TPSAB1F2PRSS1PLG
Hydrochloric Acid SCHEMBL28579078 0.92 F10 (0.82) F10TPSAB1F2PRSS1PLG
SCHEMBL7406430 0.92 F10 (0.76) F10TPSAB1F2PRSS1PLG
SCHEMBL7409221 0.92 F10 (0.66) F10TPSAB1F2PRSS1PLG
SCHEMBL7400515 0.92 F10 (0.67) F10TPSAB1F2PRSS1PLG
Hydrochloric Acid SCHEMBL30386514 0.92 F10 (0.82) F10TPSAB1F2PRSS1PLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9949474-B2 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue TRUCKEE APPLIED GENOMICS, LLC (US) 2018-04-24 US claimed
US-9445586-B2 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue TRUCKEE APPLIED GENOMICS, LLC (US) 2016-09-20 US claimed
US-20160235055-A1 METHODS AND REAGENTS FOR MAINTAINING THE VIABILITY OF CANCER CELLS IN SURGICALLY REMOVED TISSUE TRUCKEE APPLIED GENOMICS, LLC 2016-08-18 US claimed
EP-1727551-B1 PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN ARROW THERAPEUTICS LTD (GB) 2009-09-09 EP claimed
US-7569342-B2 Removal of molecular assay interferences SIERRA MOLECULAR CORP. (US) 2009-08-04 US claimed
EP-1727550-B1 PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND AN INHIBITOR OF THE RSV FUSION PROTEIN ARROW THERAPEUTICS LTD (GB) 2009-07-29 EP claimed
EP-2076595-A2 REMOVAL OF MOLECULAR ASSAY INTERFERENCES FOR NUCLEIC ACIDS EMPLOYING BUFFERED SOLUTIONS OF CHAOTROPES Sierra Molecular Corporation (US) 2009-07-08 EP claimed
US-20080171691-A1 Inhibition of invasive remodelling LUND LEIF ROGE 2008-07-17 US claimed
US-20080124728-A1 Removal of Molecular Assay Interferences for Nucleic Acids Employing Buffered Solutions of Chaotropes SIERRA MOLECULAR CORPORATION 2008-05-29 US claimed
WO-2008033936-A2 REMOVAL OF MOLECULAR ASSAY INTERFERENCES FOR NUCLEIC ACIDS EMPLOYING BUFFERED SOLUTIONS OF CHAOTROPES SIERRA MOLECULAR CORPORATION (US) 2008-03-20 WO claimed
US-20040116407-A1 Combinations of drugs for the treatment of neoplasms COMBINATORX, INC. 2004-06-17 US claimed
WO-2004006842-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
WO-2004006849-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
US-6583149-B1 2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-Dioxolane BIOCHEM PHARMA INC. (CA) 2003-06-24 US claimed
US-20020102580-A1 Removal of molecular assay interferences SIERRA MOLECULAR CORP. 2002-08-01 US claimed
US-20020099004-A1 Inhibition of invasive remodelling LUND LEIF ROGE (DK) 2002-07-25 US claimed
EP-0942746-A1 INHIBITION OF INVASIVE REMODELLING FONDEN TIL FREMME AF EKSPERIMENTEL CANCERFORSKNING (DK) 1999-09-22 EP claimed
WO-1998024474-A1 INHIBITION OF INVASIVE REMODELLING FONDEN TIL FREMME AF EKSPERIMENTEL CANCERFORSKNING (DK) 1998-06-11 WO claimed
US-4940723-A Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL (US) 1990-07-10 US claimed
US-4324794-A PREVENTION OF EPIDEMICS BY PROPHYLACTIC ADMINISTRATION RESEARCH TRIANGLE INSTITUTE (US) 1982-04-13 US claimed