Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573711 | 0.86 | LMNA (0.73) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL9246238 | 0.81 | LMNA (0.72) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL6569993 | 0.81 | LMNA (0.68) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL26757980 | 0.80 | LMNA (0.78) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL2969374 | 0.80 | SMN1; SMN2 (0.74) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL3578232 | 0.79 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7527718 | 0.77 | LMNA (0.77) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL2961916 | 0.77 | SMN1; SMN2 (0.67) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL6573530 | 0.77 | CYP2C19 (0.74) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL2969262 | 0.77 | SMN1; SMN2 (0.66) | LMNASMN1; SMN2MEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |