⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920373 | 0.82 | — | — | |
| SCHEMBL1766663 | 0.82 | — | — | |
| SCHEMBL19441651 | 0.80 | ADH1A (0.33) | — | |
| SCHEMBL1921081 | 0.78 | — | — | |
| SCHEMBL25238328 | 0.78 | — | — | |
| SCHEMBL12252323 | 0.75 | — | — | |
| SCHEMBL13560923 | 0.75 | — | — | |
| SCHEMBL456403 | 0.73 | — | — | |
| SCHEMBL5397792 | 0.69 | — | — | |
| SCHEMBL25284873 | 0.67 | ADH1A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848617-B1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-01-12 | — | — | EP | disclosed |
| US-9751882-B2 | Diaryl[A, G]quinolizidine compound, preparation method therefor, pharmaceutical composition, and uses thereof | KINGSOUND & PARTNER (CN) | 2017-09-05 | — | — | US | disclosed |
| US-20150141419-A1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-21 | — | — | US | disclosed |
| EP-2848617-A1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2015-03-18 | — | — | EP | disclosed |
| EP-2497475-A1 | Treatment of laminitis with platelet aggregation inhibitors | Dussler, Sabine (DE) | 2012-09-12 | — | — | EP | disclosed |
| CN-100369896-C | Cyclic amine compound | SANKYO CO (JP) | 2008-02-20 | — | — | CN | disclosed |
| CN-1192019-C | Cyclic amine derivatives | SANKYO CO (JP) | 2005-03-09 | — | — | CN | disclosed |
| EP-0934928-B1 | CYCLIC AMINE DERIVATIVES | SANKYO CO (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6610708-B1 | Anticoagulants | SANKYO COMPANY, LIMITED (JP) | 2003-08-26 | — | — | US | disclosed |
| CN-1107502-C | Preparation method for medicinal composition containing hydrogenated pyridine derivative as active components | SANKYO CO (JP) | 2003-05-07 | — | — | CN | disclosed |
| US-6087379-A | AN ANTICOAGULANT FOR THE TREATMENT AND PREVENTION OF DISEASES AS EMBOLISM, THROMBOSIS OR ARTERIOSCLEROSIS | SANKYO COMPANY, LIMITED (JP) | 2000-07-11 | — | — | US | disclosed |
| EP-0934928-A1 | CYCLIC AMINE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1999-08-11 | — | — | EP | disclosed |
| CN-1217186-A | Preparation method for medicinal composition containing hydrogenated pyridine derivative as active components | SANKYO CO (JP) | 1999-05-26 | — | — | CN | disclosed |
| CN-1041730-C | Process for preparing hydrogenated pyridine derivatives | SANKYO CO (JP) | 1999-01-20 | — | — | CN | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5436242-A | Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof for inhibiting blood platelet aggregation | SANKYO COMPANY, LIMITED (JP) | 1995-07-25 | — | — | US | disclosed |
| US-5288726-A | Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation | UBE INDUSTRIES LIMITED (JP) | 1994-02-22 | — | — | US | disclosed |
| CN-1074446-A | Hydroxypyridine Derivatives | SANKYO CO (JP) | 1993-07-21 | — | — | CN | disclosed |
| EP-0542411-A2 | Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation | Sankyo Company Limited (JP) | 1993-05-19 | — | — | EP | disclosed |