Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11726345 | 1.00 | MAPK1 (0.43) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL6573616 | 1.00 | MAPK1 (0.43) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL11724429 | 0.98 | HPGD (0.43) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL11722397 | 0.95 | MAPK1 (0.44) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL15598874 | 0.95 | MAPK1 (0.44) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL11722394 | 0.95 | MAPK1 (0.44) | MAPK1HPGDHSD17B10ESR2LMNA | |
| SCHEMBL8190673 | 0.81 | TSHR (0.42) | HCAR2USP2 | |
| SCHEMBL18820281 | 0.81 | TSHR (0.42) | HCAR2USP2 | |
| SCHEMBL8190669 | 0.81 | TSHR (0.42) | HCAR2USP2 | |
| SCHEMBL9535027 | 0.79 | TSHR (0.41) | HCAR2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| EP-0934928-B1 | CYCLIC AMINE DERIVATIVES | SANKYO CO (JP) | 2004-10-13 | — | — | EP | disclosed |