Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18820281 | 1.00 | TSHR (0.42) | TSHRFKBP5CRBNKEAP1NFE2L2 | |
| SCHEMBL8190673 | 1.00 | TSHR (0.42) | TSHRFKBP5CRBNKEAP1NFE2L2 | |
| SCHEMBL9535027 | 0.98 | TSHR (0.41) | TSHRFKBP5CRBNKEAP1NFE2L2 | |
| SCHEMBL9535032 | 0.98 | TSHR (0.41) | TSHRFKBP5CRBNKEAP1NFE2L2 | |
| SCHEMBL4954046 | 0.94 | TSHR (0.44) | TSHRKEAP1NFE2L2HCAR2 | |
| SCHEMBL9612293 | 0.94 | TSHR (0.44) | TSHRKEAP1NFE2L2HCAR2 | |
| SCHEMBL4954055 | 0.94 | TSHR (0.44) | TSHRKEAP1NFE2L2HCAR2 | |
| SCHEMBL6573614 | 0.81 | MAPK1 (0.43) | HCAR2USP2 | |
| SCHEMBL6573616 | 0.81 | MAPK1 (0.43) | HCAR2USP2 | |
| SCHEMBL11726345 | 0.81 | MAPK1 (0.43) | HCAR2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| US-6147087-A | SELECTIVE POTASSIUM CHANNEL MODULATORS, IN PARTICULAR FOR THE TREATMENT OF THE CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-14 | — | — | US | disclosed |
| US-5990121-A | SUCH AS METHYL 6-(3-NITROPHENYL)-7-OXO-1,2,3,4,6,7,8,9,10-NONAHYDROPYRIDO(1,2-A)QUINOLINE-5-CARBOXYLATE; USEFUL AS POTASSIUM CHANNEL MODULATORS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS DEMENTIA | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-23 | — | — | US | disclosed |
| US-4053614-A | 1,2-PENTAMETHYLENE-1,4-DIHYDROPYRIDINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-11 | — | — | US | disclosed |
| US-4024261-A | HYPERTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | disclosed |
| US-4004015-A | Bicyclic derivatives of 1,4-dihydropyridine as antihypertensive agents and coronary vessel dilators | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-18 | — | — | US | disclosed |
| US-3951994-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3951988-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3948923-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
| US-3935220-A | VASODILATION, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |