Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | PTPRC | P08575 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576345 | 0.88 | TTR (0.45) | SLC6A3SLC6A4SLC6A2TTRALDH1A1 | |
| SCHEMBL22292439 | 0.84 | KDM4E (0.54) | ALDH1A1TSHRLMNAKDM4EMEN1 | |
| SCHEMBL12928420 | 0.82 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2ALDH1A1PTPRC | |
| Bicarbonate SCHEMBL27492792 | 0.81 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2ALDH1A1TSHR | |
| SCHEMBL9549 | 0.81 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2ALDH1A1PTPRC | |
| SCHEMBL27532181 | 0.79 | TSHR (0.51) | SLC6A3SLC6A4SLC6A2TTRALDH1A1 | |
| SCHEMBL1170268 | 0.79 | KDM4E (0.47) | ALDH1A1TSHRLMNAKDM4EMAPT | |
| SCHEMBL6437163 | 0.79 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2ALDH1A1TSHR | |
| SCHEMBL7570354 | 0.79 | KDM4E (0.53) | SLC6A3SLC6A4SLC6A2ALDH1A1TSHR | |
| SCHEMBL69464 | 0.79 | SLC6A3 (0.67) | SLC6A3SLC6A4SLC6A2ALDH1A1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435942-A1 | 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032980-A1 | 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |