Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572819 | 0.93 | ADORA3 (0.49) | ADORA3ADORA1ADORA2AADORA2BLMNA | |
| Gw493838 SCHEMBL6935807 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1ADORA2AADORA2B | |
| Gw493838 SCHEMBL6250937 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1ADORA2AADORA2B | |
| Gw493838 SCHEMBL29384676 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1ADORA2AADORA2B | |
| Gw493838 SCHEMBL6225102 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1ADORA2AADORA2B | |
| Gw493838 SCHEMBL6696560 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6573867 | 0.89 | ADORA3 (0.50) | ADORA3ADORA1ADORA2AADORA2BLMNA | |
| SCHEMBL6574679 | 0.88 | ADORA3 (0.53) | ADORA3ADORA1ADORA2AADORA2BLMNA | |
| Gw493838 SCHEMBL7192949 | 0.84 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6573870 | 0.83 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AADORA2BPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090019-B1 | ADENOSINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2004-09-29 | — | — | EP | disclosed |
| EP-1447407-A1 | Adenosine derivatives | GLAXO GROUP LIMITED (GB) | 2004-08-18 | — | — | EP | disclosed |