⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660278 | 1.00 | — | — | |
| SCHEMBL8686530 | 1.00 | — | — | |
| SCHEMBL19821509 | 0.80 | — | — | |
| SCHEMBL18651225 | 0.80 | — | — | |
| SCHEMBL5202436 | 0.75 | — | — | |
| SCHEMBL6843879 | 0.73 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL21003633 | 0.73 | — | — | |
| SCHEMBL20999997 | 0.73 | — | — | |
| SCHEMBL11801385 | 0.71 | — | — | |
| SCHEMBL2579180 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246130-A1 | DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2021-08-12 | — | — | US | disclosed |
| US-10961236-B2 | (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor | ASTRAZENECA AB (SE) | 2021-03-30 | — | — | US | disclosed |
| US-20200308164-A1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2020-10-01 | — | — | US | disclosed |
| EP-3515910-B1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2020-07-15 | — | — | EP | disclosed |
| CN-109715623-A | 5- [2- (pyridin-2-ylamino) -1, 3-thiazol-5-yl ] -2, 3-dihydro-1H-isoindol-1-one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta and gamma | 阿斯利康(瑞典)有限公司 | 2019-05-03 | — | — | CN | disclosed |
| EP-1154983-B1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6441237-B1 | DRUGS; ANTIARRHTHYMIA AGENTS, ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1154983-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000048987-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-08-24 | — | — | WO | disclosed |
| US-5731318-A | NEUROLOGICAL DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5607941-A | BENZOMORPHAN DERIVATIVES | BOEHRINGER INGELHEIM KG (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0521422-B1 | Benzomorphanes and their use as pharmaceuticals | BOEHRINGER INGELHEIM KG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0521422-A1 | Benzomorphanes and their use as pharmaceuticals | BOEHRINGER INGELHEIM KG (DE) | 1993-01-07 | — | — | EP | disclosed |
| US-4845091-A | HYPOTENSIVE AGENTS, VASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-07-04 | — | — | US | disclosed |
| EP-0006449-B1 | 2-(2-ALKOXYETHYL)-2'-HYDROXY-6.7-BENZOMORPHANE DERIVATIVES, THEIR ACID ADDITION SALTS, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | C.H. BOEHRINGER SOHN (DE) | 1982-12-08 | — | — | EP | disclosed |
| US-4293556-A | Analgesic 2-(2-alkoxy-ethyl)-2'-hydroxy-6,7-benzomorphans and salts thereof | BOEHRINGER INGELHEIM GMBH (DE) | 1981-10-06 | — | — | US | disclosed |
| EP-0006449-A1 | 2-(2-Alkoxyethyl)-2'-hydroxy-6.7-benzomorphane derivatives, their acid addition salts, medicaments containing them and process for their preparation | C.H. BOEHRINGER SOHN (DE) | 1980-01-09 | — | — | EP | disclosed |