Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.62 |
| ▸ | PPARD | Q03181 | 8/20 | 0.62 |
| ▸ | PPARA | Q07869 | 8/20 | 0.62 |
| ▸ | SMO | Q99835 | 4/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385663 | 1.00 | PPARG (0.62) | PPARGPPARDPPARASMOITGB1 | |
| SCHEMBL5385907 | 0.88 | PPARG (0.62) | PPARGPPARDPPARARAB9ANPC1 | |
| SCHEMBL5390406 | 0.84 | PPARG (0.77) | PPARGPPARDPPARAITGB1ITGB3 | |
| SCHEMBL6529018 | 0.83 | PPARG (0.62) | PPARGPPARDPPARARAB9ANPC1 | |
| SCHEMBL5395118 | 0.83 | PPARG (0.62) | PPARGPPARDPPARARAB9ANPC1 | |
| SCHEMBL5385227 | 0.81 | PPARG (0.65) | PPARGPPARDPPARARAB9ANPC1 | |
| SCHEMBL5385455 | 0.81 | PPARG (0.67) | PPARGPPARDPPARAITGB3RAB9A | |
| SCHEMBL5375774 | 0.81 | PPARG (0.92) | PPARGPPARDPPARA | |
| SCHEMBL5389303 | 0.80 | PPARG (0.76) | PPARGPPARDPPARA | |
| SCHEMBL5383883 | 0.80 | PPARA (0.84) | PPARGPPARDPPARAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392637-A2 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100813-A2 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |