SCHEMBL6575822

SCHEMBL6575822

N#CCN(C(N)=O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SERPINE1 P05121 6/20 0.45
EPHX2 P34913 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MAPT P10636 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
EPHX1 P07099 2/20 0.39
GAA P10253 2/20 0.39
POLB P06746 2/20 0.39
NPC1 O15118 1/20 0.39
NPY1R P25929 1/20 0.39
RAB9A P51151 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
MAPK8 P45983 1/20 0.38
MEN1 O00255 1/20 0.38
TP53 P04637 1/20 0.38
CYP3A4 P08684 1/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4145118 0.86 SERPINE1 (0.45) SERPINE1EPHX2ALDH1A1MAPTTDP1
SCHEMBL2086193 0.75 HCRTR2 (0.44) SERPINE1EPHX2POLBMEN1TSHR
SCHEMBL27567460 0.75 USP2 (0.46) ALDH1A1NPC1MEN1TP53CYP3A4
Hydrochloric Acid SCHEMBL6111921 0.74 ALOX5 (0.39) ALDH1A1MAPTEPHX1GAAPOLB
SCHEMBL8386558 0.73 EPHX2 (0.47) SERPINE1EPHX2MAPTEPHX1GAA
SCHEMBL31041032 0.73 HTR2C (0.43) SERPINE1EPHX2ALDH1A1EPHX1POLB
SCHEMBL5035162 0.72 EPHX2 (0.46) SERPINE1EPHX2MAPTEPHX1GAA
SCHEMBL13871456 0.72 EPHX2 (0.46) SERPINE1EPHX2ALDH1A1MAPTTDP1
SCHEMBL594774 0.72 MAPT (0.43) SERPINE1EPHX2ALDH1A1MAPTTDP1
SCHEMBL9819029 0.71 GPBAR1 (0.42) SERPINE1EPHX2TDP1POLBSLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1412334-A1 PYRAZOLINE DERIVATIVES AND THEIR USE AS PESTICIDES Bayer CropScience AG (DE) 2004-04-28 EP disclosed
WO-2003010148-A1 PYRAZOLINE DERIVATIVES AND THEIR USE AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2003-02-06 WO disclosed