Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.53 |
| ▸ | MC5R | P33032 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521675 | 0.91 | MC4R (0.61) | MC4RMC5RSIGMAR1CYP1A2ALDH1A1 | |
| SCHEMBL16790618 | 0.88 | CHRM2 (0.48) | MC4RMC5RHTR2ASIGMAR1GAA | |
| SCHEMBL11049168 | 0.86 | MC4R (0.53) | MC4RMC5RHTR2AALDH1A1KMT2A | |
| SCHEMBL13528546 | 0.86 | MAOA (0.60) | MC4RMC5RSIGMAR1CYP1A2CYP2C19 | |
| SCHEMBL14524279 | 0.85 | HRH4 (0.53) | MC4RMC5RHTR2ASIGMAR1GAA | |
| SCHEMBL14430120 | 0.84 | MC4R (0.55) | MC4RMC5RKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL6573307 | 0.83 | MC4R (0.50) | MC4RMC5RSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL7209237 | 0.82 | HTR2A (0.63) | HTR2ASIGMAR1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL12085525 | 0.81 | MC4R (0.63) | MC4RMC5RSIGMAR1CYP1A2CYP2C19 | |
| Phenethylamine SCHEMBL9229966 | 0.81 | GAA (0.77) | HTR2ASIGMAR1GAAMAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | DAVISON JOSHUA ZWICK (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1409452-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002098846-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147612-A1 | Sulfonamide derivatives | GRIN1, GRIN2A, GRIA1 | MC4R 1641/4885MC5R 757/4885HTR2A 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.