SCHEMBL6575994

SCHEMBL6575994

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NN1CCCCC1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 7/20 0.60
KMT2A Q03164 2/20 0.60
KDM4E B2RXH2 2/20 0.60
LMNA P02545 2/20 0.60
KRAS P01116 1/20 0.60
MEN1 O00255 1/20 0.60
MPO P05164 1/20 0.60
MAPT P10636 1/20 0.60
TSHR P16473 1/20 0.60
BLM P54132 1/20 0.60
PMP22 Q01453 1/20 0.60
HIF1A Q16665 1/20 0.60
DPP4 P27487 2/20 0.54
RUVBL1 Q9Y265 2/20 0.49
ALDH1A1 P00352 1/20 0.49
HTT P42858 1/20 0.49
MAPK1 P28482 1/20 0.49
BCHE P06276 1/20 0.48
ACHE P22303 1/20 0.48
JAK2 O60674 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8700328 0.86 POLB (0.60) KMT2AKDM4ELMNAMEN1MAPT
SCHEMBL8700550 0.86 POLB (0.60) KMT2AKDM4ELMNAMEN1MAPT
SCHEMBL18305783 0.82 SOS1 (0.58) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL9452845 0.82 KMT2A (0.64) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL15962425 0.81 SOS1 (0.59) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL27157037 0.81 SOS1 (0.56) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL1069904 0.80 KDM4E (0.72) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL2250392 0.80 MAPT (0.72) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL27640891 0.80 KDM4E (0.72) SOS1KMT2AKDM4ELMNAKRAS
SCHEMBL2250396 0.80 MAPT (0.72) SOS1KMT2AKDM4ELMNAKRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0558648-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 2004-04-28 EP disclosed
EP-0663823-B1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 2000-11-22 EP disclosed
US-5892112-A ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS GLYCOMED INCORPORATED (US) 1999-04-06 US disclosed
US-5773438-A SKIN DISORDERS, RESTENOSIS, RHEUMATIC ARTHRITIS, WOUND HEALING AGENTS, ANGIOGENESIS, SHOCK GLYCOMED INCORPORATED (US) 1998-06-30 US disclosed
EP-0558681-B1 TREATMENT FOR TISSUE ULCERATION UNIV FLORIDA (US) 1998-04-08 EP disclosed
US-5696147-A CONTROLLING GROWTH OF TUMORS AND NEOVASCULAR GLAUCOMAS GLYCOMED, INC. (US) 1997-12-09 US disclosed
EP-0558635-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 1997-09-10 EP disclosed
EP-0663823-A4 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS. GLYCOMED INC (US) 1997-06-04 EP disclosed
EP-0692931-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-20 EP disclosed
EP-0690841-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-13 EP disclosed
EP-0558648-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY, Richard, E. (US) 1993-09-08 EP disclosed
EP-0558635-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS. GLYCOMED INC (US) 1993-09-08 EP disclosed
US-5239078-A Collagenase enzyme inhibitors GLYCOMED INCORPORATED (US) 1993-08-24 US disclosed
WO-1993013741-A2 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1993-07-22 WO disclosed
US-5189178-A Preventing protein destruction GALARDY RICHARD E (US) 1993-02-23 US disclosed
US-5183900-A Matrix metalloprotease inhibitors GALARDY RICHARD E (US) 1993-02-02 US disclosed
WO-1992009563-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1992-06-11 WO disclosed
WO-1992009556-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 1992-06-11 WO disclosed
WO-1992009282-A1 TREATMENT FOR TISSUE ULCERATION THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 1992-06-11 WO disclosed
US-5114953-A Peptides UNIVERSITY OF FLORIDA (US) 1992-05-19 US disclosed