Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700550 | 1.00 | POLB (0.60) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL8700131 | 0.89 | MAPT (0.57) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL6575994 | 0.86 | SOS1 (0.60) | KDM4EMAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL7678243 | 0.82 | KDM4E (0.59) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7854107 | 0.81 | KDM4E (0.70) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7670517 | 0.81 | KDM4E (0.60) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7852936 | 0.81 | POLB (0.55) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL20713624 | 0.80 | POLB (0.72) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7675962 | 0.79 | MMP2 (0.63) | POLBKDM4EMAPTAPAF1RECQL | |
| SCHEMBL7848162 | 0.79 | KDM4E (0.51) | POLBKDM4EMAPTAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846942-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1998-12-08 | — | — | US | claimed |