Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581282 | 0.88 | MEN1 (0.55) | BDKRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL4600297 | 0.87 | BDKRB2 (0.60) | BDKRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL6576124 | 0.84 | MEN1 (0.57) | BDKRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL6576066 | 0.83 | BDKRB2 (0.60) | BDKRB2MEN1KMT2A | |
| SCHEMBL6580680 | 0.79 | MEN1 (0.58) | BDKRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL6576231 | 0.78 | MAPT (0.40) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6581449 | 0.78 | MEN1 (0.59) | BDKRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL7746973 | 0.77 | BDKRB2 (0.82) | BDKRB2MEN1KMT2A | |
| SCHEMBL7914190 | 0.77 | BDKRB2 (0.50) | BDKRB2 | |
| SCHEMBL6578892 | 0.76 | BDKRB2 (0.57) | BDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |