Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252633 | 0.98 | NAMPT (0.45) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL5331486 | 0.92 | NAMPT (0.46) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL30125632 | 0.92 | NAMPT (0.46) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL2072460 | 0.91 | NAMPT (0.54) | NAMPTGRM1GRM4ROCK2ROCK1 | |
| SCHEMBL14388685 | 0.90 | NAMPT (0.46) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL6433630 | 0.89 | NAMPT (0.45) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL31615222 | 0.88 | HDAC1 (0.51) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL23728665 | 0.88 | HDAC1 (0.57) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL23728539 | 0.88 | HDAC1 (0.57) | NAMPTERBB2HDAC1HDAC2HDAC8 | |
| SCHEMBL20485621 | 0.88 | NAMPT (0.52) | NAMPTGRM1GRM4ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430028-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | Pharmacia Corporation (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1421056-A1 | (ALPHA)-HALOENAMINE REAGENTS | Pharmacia Corporation (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003020684-A1 | (ALPHA)-HALOENAMINE REAGENTS | PHARMACIA CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003018552-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | PHARMACIA CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |