Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24630353 | 0.98 | NAMPT (0.43) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL12934351 | 0.91 | NAMPT (0.52) | NAMPTKDM4EPOLBMAPTGRM1 | |
| SCHEMBL6576406 | 0.89 | NAMPT (0.46) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL23728629 | 0.89 | HDAC1 (0.55) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL23745008 | 0.89 | HDAC1 (0.55) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL5335787 | 0.89 | NAMPT (0.50) | NAMPTKDM4EPOLBMAPTGRM1 | |
| SCHEMBL31180744 | 0.88 | HDAC1 (0.53) | HDAC1HDAC2HDAC8KDM4EPOLB | |
| SCHEMBL14388685 | 0.88 | NAMPT (0.46) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL25252633 | 0.87 | NAMPT (0.45) | NAMPTHDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL5331221 | 0.86 | NAMPT (0.46) | NAMPTKDM4EPOLBMAPTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924396-B2 | α-haloenamine reagents | PHARMACIA CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1430028-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | Pharmacia Corporation (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1421056-A1 | (ALPHA)-HALOENAMINE REAGENTS | Pharmacia Corporation (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20040092770-A1 | Alpha-haloenamine reagents | PHARMACIA CORPORATION | 2004-05-13 | — | — | US | disclosed |
| US-6677487-B2 | COMBINING A TERTIARY AMIDE WITH A PENTAVALENT PHOSPHOROUS HALIDE IN A SOLVENT TO FORM AN ALPHA - HALOIMINIUM SALT AND CONVERTING THE ALPHA -HALOIMINIUM SALT TO THE ALPHA -HALOENAMINE WITH A BASE | PHARMACIA CORPORATION | 2004-01-13 | — | — | US | disclosed |
| US-20030105279-A1 | Aromatic and heteroaromatic acid halides for synthesizing polyamides | PHARMACIA CORPORATION | 2003-06-05 | — | — | US | disclosed |
| US-20030080320-A1 | Alpha- haloenamine reagents | PHARMACIA CORPORATION | 2003-05-01 | — | — | US | disclosed |
| WO-2003020684-A1 | (ALPHA)-HALOENAMINE REAGENTS | PHARMACIA CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003018552-A2 | AROMATIC AND HETEROAROMATIC ACID HALIDES FOR SYNTHESIZING POLYAMIDES | PHARMACIA CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030080320-A1 | Alpha- haloenamine reagents | HNMT, HDHD5, NISCH | NAMPT 1822/4885HDAC1 2027/4885HDAC2 1655/4885 |
| US-20040092770-A1 | Alpha-haloenamine reagents | HNMT, HDHD5, NISCH | NAMPT 1822/4885HDAC1 2027/4885HDAC2 1655/4885 |
| US-20030105279-A1 | Aromatic and heteroaromatic acid halides for synthesizing polyamides | AAAS, HTT, HRH4 | NAMPT 3894/4885HDAC1 3548/4885HDAC2 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.