Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.71 |
| ▸ | BRD4 | O60885 | 6/20 | 0.65 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.65 |
| ▸ | BRD2 | P25440 | 1/20 | 0.64 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576865 | 1.00 | MAPK14 (0.71) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL24170839 | 0.92 | MAPK14 (0.80) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579097 | 0.88 | MAPK14 (0.61) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579102 | 0.88 | MAPK14 (0.61) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6576824 | 0.88 | BRD4 (0.62) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6576610 | 0.88 | BRD4 (0.62) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579234 | 0.88 | MAPK14 (0.61) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579405 | 0.88 | BRD4 (0.62) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6576577 | 0.88 | MAPK14 (0.91) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6578912 | 0.88 | MAPK14 (0.91) | MAPK14BRD4BRDTBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961618-B1 | 5-Pyrimidinyl-4-yl-Imidazole Derivate zur Behandlung von CSBP/RK/p38 vermittelten Erkrankungen | SMITHKLINE BEECHAM CORP (US) | 2004-08-04 | — | — | EP | claimed |
| US-6369068-B1 | Amino substituted pyrimidine containing compounds | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | claimed |