Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582826 | 0.82 | HTR1A (0.52) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL18820460 | 0.76 | CHRM2 (0.38) | HTR1AADRA1B | |
| SCHEMBL9386416 | 0.76 | HTR1A (0.48) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL11608413 | 0.74 | HTR1A (0.47) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL18806137 | 0.71 | CYP11B1 (0.33) | — | |
| SCHEMBL16190005 | 0.71 | HTR1A (0.38) | HTR1AADRA1BADRA1A | |
| SCHEMBL1728235 | 0.69 | HTR1A (0.40) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL7356006 | 0.69 | HTR1A (0.50) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL39045 | 0.69 | — | — | |
| SCHEMBL31533639 | 0.68 | HTR1A (0.43) | HTR1AADRA1BADRA1AADRA1DDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |