SCHEMBL6578561

SCHEMBL6578561

NNC(=O)c1ccc(CN2CCCC2)s1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.53
KDM4E B2RXH2 3/20 0.51
GAA P10253 1/20 0.51
HIF1A Q16665 1/20 0.49
EPAS1 Q99814 1/20 0.49
ALDH1A1 P00352 3/20 0.47
MAPT P10636 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
HTT P42858 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
EPHX2 P34913 5/20 0.45
POLB P06746 1/20 0.44
HPGD P15428 1/20 0.44
IKBKE Q14164 3/20 0.42
TBK1 Q9UHD2 3/20 0.42
AOC3 Q16853 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8171401 0.98 HRH3 (0.55) HRH3KDM4EGAAHIF1AEPAS1
SCHEMBL8183430 0.84 AOC3 (0.45) HRH3KDM4EGAAALDH1A1MAPT
SCHEMBL8178308 0.83 HRH3 (0.58) HRH3KDM4EGAAHIF1AEPAS1
SCHEMBL3592586 0.82 HRH3 (0.57) HRH3KDM4EHIF1AEPAS1ALDH1A1
SCHEMBL6580820 0.81 HRH3 (0.56) HRH3KDM4EHIF1AEPAS1ALDH1A1
SCHEMBL8184741 0.79 HRH3 (0.61) HRH3KDM4EALDH1A1MAPTL3MBTL1
SCHEMBL8179534 0.79 HRH3 (0.58) HRH3KDM4EHIF1AEPAS1ALDH1A1
Hydrochloric Acid SCHEMBL8176778 0.79 HRH3 (0.58) HRH3KDM4EHIF1AEPAS1ALDH1A1
SCHEMBL8176935 0.76 HRH3 (0.51) HRH3KDM4EGAAHIF1AEPAS1
SCHEMBL10648005 0.76 HRH3 (0.51) HRH3KDM4EHIF1AEPAS1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP disclosed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US disclosed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP disclosed
US-6090804-A PSYCHOLOGICAL DISORDERS; SCHIZOPHRENIA THERAPY YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2000-07-18 US disclosed
EP-0921123-A1 NOVEL THIOPHENE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1999-06-09 EP disclosed