Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823243 | 0.88 | HRH3 (0.60) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL16761062 | 0.87 | ALDH1A1 (0.54) | HRH3ALDH1A1HPGDNPSR1L3MBTL1 | |
| SCHEMBL8177110 | 0.85 | HRH3 (0.55) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL3592586 | 0.85 | HRH3 (0.57) | HRH3ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL8184741 | 0.83 | HRH3 (0.61) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL8176778 | 0.83 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL6578561 | 0.81 | HRH3 (0.53) | HRH3ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL8171401 | 0.80 | HRH3 (0.55) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL8179534 | 0.79 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL8178308 | 0.79 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |