Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 13/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16533069 | 0.87 | MAPT (0.48) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL12365605 | 0.85 | LMNA (0.49) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL6582881 | 0.84 | KCNQ3 (0.54) | LMNAMAPK1HTTRAB9AKMT2A | |
| SCHEMBL6581244 | 0.84 | LMNA (0.50) | LMNAMAPK1HTTRAB9AKMT2A | |
| SCHEMBL5533467 | 0.84 | FFAR1 (0.52) | LMNAMAPK1HTTRAB9AFFAR1 | |
| SCHEMBL24933562 | 0.83 | KMT2A (0.71) | MAPK1MEN1KMT2ATSHR | |
| SCHEMBL1495947 | 0.83 | MEN1 (0.51) | LMNAMEN1KMT2APPARDPPARG | |
| SCHEMBL30163184 | 0.83 | KMT2A (0.71) | MAPK1MEN1KMT2ATSHR | |
| SCHEMBL13125223 | 0.83 | EGFR (0.50) | LMNAMAPK1HTTRAB9AKMT2A | |
| SCHEMBL6581250 | 0.82 | LMNA (0.42) | LMNAMAPK1HTTRAB9ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |