Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936587 | 0.88 | BDKRB2 (0.66) | BDKRB2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6644122 | 0.87 | BDKRB2 (0.65) | BDKRB2MEN1KMT2A | |
| SCHEMBL6580622 | 0.87 | BDKRB2 (0.55) | BDKRB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6580766 | 0.86 | BDKRB2 (0.54) | BDKRB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6578383 | 0.83 | BDKRB2 (0.51) | BDKRB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6578777 | 0.83 | BDKRB2 (0.62) | BDKRB2MEN1KMT2APTGDR2 | |
| SCHEMBL6581519 | 0.82 | MCHR1 (0.50) | BDKRB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6580680 | 0.81 | MEN1 (0.58) | BDKRB2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6580497 | 0.79 | BDKRB2 (0.57) | BDKRB2 | |
| SCHEMBL7746973 | 0.79 | BDKRB2 (0.82) | BDKRB2MEN1KMT2AKDM4EPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6211196-B1 | 8-BENZYLOXY-(TETRAHYDRO)QUINOLINE DERIVATIVES; LIVER CIRRHOSIS, ALZHEIMER*S DISEASE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |