Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.51 |
| ▸ | PPARA | Q07869 | 11/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15446177 | 0.80 | TACR1 (0.50) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL15446186 | 0.79 | PPARG (0.47) | PPARGPPARAPPARDPTPN1CTSL | |
| SCHEMBL15446181 | 0.79 | PPARG (0.47) | PPARGPPARAPPARDPTPN1CTSL | |
| SCHEMBL15446189 | 0.78 | PPARG (0.52) | PPARGPPARAPPARDHDAC1HDAC6 | |
| SCHEMBL15446173 | 0.78 | PPARG (0.52) | PPARGPPARAPPARDHDAC1HDAC6 | |
| SCHEMBL22764865 | 0.75 | CTSB (0.50) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL29163290 | 0.75 | PPARG (0.65) | PPARGPPARAPTPN1 | |
| SCHEMBL22231349 | 0.74 | PPARG (0.74) | PPARGPPARAPPARDCTSLCTSB | |
| SCHEMBL6579224 | 0.74 | PPARG (0.50) | PPARGPPARAPPARDPTPN1 | |
| SCHEMBL6579229 | 0.74 | PPARG (0.50) | PPARGPPARAPPARDKMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000649-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |