Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 11/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027488 | 0.87 | ADRA2A (0.61) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7742092 | 0.78 | ADRA2A (0.67) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Povafonidine SCHEMBL6581181 | 0.78 | ADRA2A (0.67) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7028091 | 0.78 | ADRA2A (1.00) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Povafonidine SCHEMBL8927783 | 0.77 | ADRA2A (0.66) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL8690213 | 0.77 | ADRA2A (0.66) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11788766 | 0.76 | HTR1D (0.48) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6785544 | 0.74 | ADRA2A (0.58) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7025901 | 0.74 | ADRA2A (0.57) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7033369 | 0.73 | ADRA2A (0.58) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | claimed |
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6486190-B1 | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability | THE PROCTER & GAMBLE COMPANY | 2002-11-26 | — | — | US | disclosed |
| EP-1037887-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999026942-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |