Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CBS | P35520 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097075 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6581514 | 0.85 | PIM1 (0.44) | TSHRKDM4EALDH1A1GAAADRB3 | |
| SCHEMBL12559628 | 0.85 | GBA1 (0.42) | TSHRKDM4EALDH1A1HPGDGLA | |
| SCHEMBL29051576 | 0.84 | CYP4F2 (0.39) | TSHRKDM4EALDH1A1GAAADRB3 | |
| SCHEMBL10567911 | 0.84 | KDM4E (0.37) | TSHRKDM4EALDH1A1GLAGAA | |
| SCHEMBL6582027 | 0.80 | PTGS1 (0.37) | TSHRKDM4EALDH1A1GAAADRB3 | |
| SCHEMBL9385296 | 0.80 | ADRB3 (0.43) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL8921162 | 0.79 | MAPT (0.43) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL433879 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6582078 | 0.77 | PDE4B (0.38) | GBA1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005458-B1 | CARBOSTYRIL DERIVATIVES FOR INHIBITING SKIN ERYTHEMA AND/OR SKIN PIGMENTATION | OTSUKA PHARMA CO LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6133264-A | Carbostyril derivatives for inhibiting skin erythema and/or skin pigmentation | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |