SCHEMBL6579745

SCHEMBL6579745

CCOC(=O)c1ccc(N)cc1N(C)C(=O)COc1ccc(O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.48
HSD17B10 Q99714 3/20 0.48
TP53 P04637 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CA12 O43570 3/20 0.45
CA1 P00915 3/20 0.45
CA2 P00918 3/20 0.45
CA7 P43166 3/20 0.45
CA9 Q16790 3/20 0.45
CA14 Q9ULX7 3/20 0.45
HPGD P15428 2/20 0.41
CYP1A2 P05177 2/20 0.40
CYP2D6 P10635 1/20 0.40
SCN1A P35498 1/20 0.40
SCN2A Q99250 1/20 0.40
SCN3A Q9NY46 1/20 0.40
TSHR P16473 2/20 0.40
MAPK10 P53779 1/20 0.40
ESR1 P03372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6579313 0.91 SMN1; SMN2 (0.43) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6579783 0.90 TSHR (0.48) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6579028 0.85 CA12 (0.44) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6581436 0.84 LMNA (0.44) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6581483 0.83 TDP1 (0.46) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6581391 0.83 SMN1; SMN2 (0.48) LMNAHSD17B10TP53MEN1KMT2A
SCHEMBL6579573 0.81 TSHR (0.48) HSD17B10TP53MEN1KMT2AHPGD
SCHEMBL7996804 0.81 CYP1A2 (0.43) LMNAHSD17B10MEN1KMT2ACA12
SCHEMBL8002604 0.80 CYP1A2 (0.45) LMNAHSD17B10MEN1KMT2ACA12
SCHEMBL6582847 0.79 KMT2A (0.43) LMNAHSD17B10MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927718-B1 Quinolinone derivative, method for preparing the same, and anti-allergic agent DAINIPPON INK & CHEMICALS (JP) 2004-02-25 EP disclosed
US-6271416-B1 O-(HYDROCARBONOXYACETAMIDO)BENZOIC ACID DERIVATIVES AS INTERMEDIATES DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-08-07 US disclosed
US-6136822-A ETHER, HYDROXY QUINOLINONE COMPOUNDS DAINIPPON INK AND CHEMICALS, INC. (JP) 2000-10-24 US disclosed
EP-0927718-A1 Quinolinone derivative, method for preparing the same, and anti-allergic agent DAINIPPON INK AND CHEMICALS, INC. (JP) 1999-07-07 EP disclosed