Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 9/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265839 | 0.86 | KDM4E (0.74) | KDM4ETDP1NAPRTNPC1RAB9A | |
| SCHEMBL4782635 | 0.85 | MAPT (0.55) | KDM4ETDP1NAPRTNPC1RAB9A | |
| SCHEMBL2346128 | 0.83 | KDM4E (0.59) | KDM4ETDP1NAPRTALDH1A1CYP3A4 | |
| SCHEMBL2555756 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1CYP3A4 | |
| SCHEMBL6206542 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTRAB9AALDH1A1 | |
| SCHEMBL29574354 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTRAB9AALDH1A1 | |
| SCHEMBL3820615 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTNPC1RAB9A | |
| SCHEMBL29950470 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTNPC1RAB9A | |
| SCHEMBL16547426 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTNPC1RAB9A | |
| SCHEMBL10000544 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140083-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6469018-B1 | INHIBITING CYTOKINES AND THE TREATMENT OF A CYTOKINE MEDIATED DISEASE, BY ADMINISTRATION OF COMPOUNDS SUCH AS:2-(4-FLUOROPHENYL)-3-(2-METHYLTHIOPYRIMIDIN-4-YL)PYRIDINE | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |
| EP-1140083-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040243-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |