Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265839 | 0.86 | KDM4E (0.74) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL3820615 | 0.83 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL28677174 | 0.81 | PARP1 (0.45) | KDM4ETDP1NAPRTALDH1A1MAPT | |
| SCHEMBL6206542 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL2555756 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL6579855 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL10000544 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL29574354 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL16547426 | 0.80 | KDM4E (0.65) | KDM4ETDP1NAPRTALDH1A1ALOX15 | |
| SCHEMBL270419 | 0.80 | KDM4E (1.00) | KDM4ETDP1NAPRTALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | disclosed |