Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580036 | 0.81 | KCNJ1 (0.47) | KCNJ1NOTUMMAPTLMNAALDH1A1 | |
| SCHEMBL311297 | 0.80 | KCNJ1 (0.54) | KCNJ1NOTUMPTGS2MAPTLMNA | |
| SCHEMBL8523742 | 0.80 | KCNJ1 (0.50) | KCNJ1NOTUMPTGS2MAPTLMNA | |
| SCHEMBL8466868 | 0.77 | KCNJ1 (0.50) | KCNJ1NOTUMPTGS2MAPTLMNA | |
| SCHEMBL8530663 | 0.77 | HPGD (0.54) | KCNJ1LMNAALDH1A1KMT2A | |
| SCHEMBL6581553 | 0.76 | KCNJ1 (0.46) | KCNJ1NOTUMMAPTLMNAALDH1A1 | |
| SCHEMBL310636 | 0.73 | KCNJ1 (0.58) | KCNJ1NOTUMMAPTLMNAALDH1A1 | |
| SCHEMBL8531830 | 0.69 | KCNJ1 (0.54) | KCNJ1NOTUMMAPTLMNAALDH1A1 | |
| SCHEMBL1663879 | 0.66 | KCNJ1 (1.00) | KCNJ1NOTUMMAPTLMNAALDH1A1 | |
| SCHEMBL2731717 | 0.65 | KCNJ1 (0.49) | KCNJ1PTGS2MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802912-B1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LTD (GB) | 2004-10-13 | — | — | EP | disclosed |
| US-6020346-A | Piperidine derivatives having tachykinin antagonist activity | GLAXO WELLCOME INC. (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0802912-A1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021661-A1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 1996-07-18 | — | — | WO | disclosed |