Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530663 | 0.83 | HPGD (0.54) | KCNJ1ALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL6580036 | 0.80 | KCNJ1 (0.47) | KCNJ1ALDH1A1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL311297 | 0.78 | KCNJ1 (0.54) | KCNJ1ALDH1A1LMNAKMT2AHTT | |
| SCHEMBL6580030 | 0.76 | KCNJ1 (0.48) | KCNJ1ALDH1A1LMNAKMT2AHTT | |
| SCHEMBL8523742 | 0.75 | KCNJ1 (0.50) | KCNJ1ALDH1A1LMNAKMT2AHTT | |
| SCHEMBL8466868 | 0.75 | KCNJ1 (0.50) | KCNJ1ALDH1A1LMNAKMT2AHTT | |
| SCHEMBL5822990 | 0.74 | TACR1 (0.40) | — | |
| SCHEMBL18783932 | 0.71 | MEN1 (0.49) | ALDH1A1KMT2ATDP1KDM4EHPGD | |
| SCHEMBL29964746 | 0.71 | PTGDR2 (0.57) | ALDH1A1POLBTDP1L3MBTL1HPGD | |
| SCHEMBL17061451 | 0.71 | PTGDR2 (0.57) | ALDH1A1POLBTDP1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802912-B1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LTD (GB) | 2004-10-13 | — | — | EP | disclosed |
| US-6020346-A | Piperidine derivatives having tachykinin antagonist activity | GLAXO WELLCOME INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-5750549-A | ANTIINFLAMMATORY AGENTS OR ANALGESICS | MERCK & CO., INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0802912-A1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021661-A1 | PIPERIDINE DERIVATIVES HAVING TACHYKININ ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 1996-07-18 | — | — | WO | disclosed |