Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.45 |
| ▸ | EDNRB | P24530 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323946 | 0.94 | EDNRB (0.40) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6580198 | 0.92 | EDNRA (0.44) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7501396 | 0.92 | EDNRA (0.45) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6580281 | 0.91 | KDM4E (0.39) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6579920 | 0.89 | EDNRA (0.46) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6580054 | 0.88 | BRS3 (0.39) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL6580208 | 0.87 | EDNRB (0.45) | EDNRAEDNRB | |
| SCHEMBL8434873 | 0.87 | EDNRA (0.45) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL8434942 | 0.85 | BRS3 (0.42) | KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3839001 | 0.84 | EDNRA (0.45) | EDNRAEDNRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | claimed |
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | disclosed |
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |