Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.45 |
| ▸ | EDNRA | P25101 | 4/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330624 | 0.94 | EDNRB (0.40) | EDNRBEDNRABRS3TP53 | |
| SCHEMBL8434873 | 0.90 | EDNRA (0.45) | EDNRBEDNRABRS3TP53 | |
| SCHEMBL6582508 | 0.89 | EDNRA (0.43) | EDNRBEDNRA | |
| SCHEMBL7501396 | 0.88 | EDNRA (0.45) | EDNRBEDNRABRS3 | |
| SCHEMBL6580124 | 0.88 | MEN1 (0.41) | EDNRBEDNRABRS3TP53 | |
| SCHEMBL6580278 | 0.87 | EDNRA (0.45) | EDNRBEDNRA | |
| SCHEMBL3839001 | 0.86 | EDNRA (0.45) | EDNRBEDNRABRS3TP53 | |
| SCHEMBL7502700 | 0.84 | EDNRA (0.43) | EDNRBEDNRABRS3TP53 | |
| SCHEMBL7496916 | 0.84 | EDNRA (0.54) | EDNRBEDNRABRS3 | |
| SCHEMBL8431736 | 0.83 | BRS3 (0.42) | EDNRABRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804435-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-03-10 | — | — | EP | disclosed |
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |