Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380082 | 0.94 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL9138101 | 0.87 | HDAC3 (0.71) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL30297726 | 0.87 | NPC1 (0.64) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL1545565 | 0.87 | NPC1 (0.64) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL4072403 | 0.86 | HPGD (0.70) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL5389653 | 0.86 | HPGD (0.70) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL6228768 | 0.85 | HDAC3 (0.68) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL794685 | 0.84 | HDAC3 (0.72) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL13487712 | 0.84 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC11HPGD | |
| SCHEMBL13059439 | 0.84 | HDAC3 (0.67) | HDAC3HDAC1HDAC10HDAC11HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299380-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-06-09 | — | — | EP | disclosed |
| US-20030232822-A1 | Indole derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DE) | 2003-12-18 | — | — | US | disclosed |
| EP-1299380-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000645-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232822-A1 | Indole derivatives useful for the treatment of CNS disorders | CHRM1, TPH1, CHRNA6 | HDAC3 352/4885HDAC1 1265/4885HDAC10 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.