Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6576231 | 0.87 | MAPT (0.40) | MAPTALDH1A1NPC1SMN1; SMN2S1PR4 | |
| SCHEMBL6578371 | 0.86 | ALDH1A1 (0.44) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6580686 | 0.85 | S1PR4 (0.44) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6578500 | 0.84 | ALDH1A1 (0.43) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6578390 | 0.83 | NQO1 (0.41) | MAPTALDH1A1RAB9ANPC1NQO1 | |
| SCHEMBL6580761 | 0.82 | MAPT (0.42) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6581282 | 0.80 | MEN1 (0.55) | MAPTALDH1A1RAB9APOLBMEN1 | |
| SCHEMBL6581453 | 0.77 | ALDH1A1 (0.40) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6576127 | 0.77 | S1PR4 (0.42) | MAPTALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL6581385 | 0.76 | TP53 (0.42) | MAPTALDH1A1NPC1SMN1; SMN2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |