Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330904 | 0.80 | MAPT (0.61) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL8825635 | 0.80 | NOTUM (0.60) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL8825392 | 0.78 | MAPT (0.58) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL16592426 | 0.78 | NPC1 (0.76) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL11715801 | 0.78 | NPC1 (0.76) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL12797808 | 0.77 | NPC1 (0.70) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL8657046 | 0.76 | MAPT (0.57) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL7566386 | 0.76 | MAPT (0.57) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL27412663 | 0.76 | NPC1 (0.74) | MAPTRAB9ANPC1CHRNB2CHRNA5 | |
| SCHEMBL16592590 | 0.76 | NPC1 (0.74) | MAPTRAB9ANPC1CHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737680-B1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | SOLVAY PHARM GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-0737680-A1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1996-10-16 | — | — | EP | disclosed |