SCHEMBL65823

SCHEMBL65823

CC1CNc2ccn1c(=O)n2

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 1/20 0.32
THRB P10828 1/20 0.32
MTOR P42345 1/20 0.32
MDM2 Q00987 1/20 0.32
NCOA1 Q15788 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
GSK3B P49841 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31569523 0.63 HRH3 (0.38)
SCHEMBL20100285 0.59 PARP1 (0.38) MEN1KMT2ALMNA
SCHEMBL24934617 0.59 RPS6KA2 (0.37)
SCHEMBL26171208 0.57 PDE3A (0.43) MEN1KMT2ALMNATHRBMTOR
SCHEMBL17490811 0.56 PIK3C3 (0.40)
SCHEMBL17490634 0.56 PIK3C3 (0.40)
SCHEMBL16402577 0.56 PIK3C3 (0.40)
SCHEMBL12059178 0.55
SCHEMBL24707475 0.55
SCHEMBL13574954 0.55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188254-B2 C-class oligonucleotide analogs with enhanced immunostimulatory potency COLEY PHARMACEUTICAL GMBH (DE) 2012-05-29 US claimed
EP-1730281-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS FOR INDUCING IL-10 RESPONSES Coley Pharmaceutical Group, Inc. (US) 2006-12-13 EP claimed
EP-1728863-A2 C-class oligonucleotide analogs with enhanced immunostimulatory potency Coley Pharmaceutical GmbH (DE) 2006-12-06 EP claimed
EP-1678303-A2 C-CLASS OLIGONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY POTENCY Coley Pharmaceutical GmbH (DE) 2006-07-12 EP claimed
WO-2005111057-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS FOR INDUCING IL-10 RESPONSES COLEY PHARMACEUTICAL GROUP, INC. (US) 2005-11-24 WO claimed
US-20050239734-A1 C-class oligonucleotide analogs with enhanced immunostimulatory potency COLEY PHARMACEUTICAL GMBH (DE) 2005-10-27 US claimed
EP-1578954-A2 5' CPG NUCLEIC ACIDS AND METHODS OF USE Coley Pharmaceutical Group, Inc. (US) 2005-09-28 EP claimed
WO-2005042018-A2 C-CLASS OLIGONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY POTENCY COLEY PHARMACEUTICAL GMBH (DE) 2005-05-12 WO claimed
US-20040171571-A1 5' CpG nucleic acids and methods of use COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-09-02 US claimed
WO-2004053104-A2 5’ CPG NUCLEIC ACIDS AND METHODS OF USE COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-06-24 WO claimed
US-20240230627-A1 LIGAND DISCOVERY AND GENE DELIVERY VIA RETROVIRAL SURFACE DISPLAY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2024-07-11 US disclosed
WO-2024127215-A2 IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE PFIZER INC. (US) 2024-06-20 WO disclosed
US-20240200134-A1 SINGLE CELL ANALYSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2024-06-20 US disclosed
US-20240189410-A1 IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE PFIZER (US) 2024-06-13 US disclosed
US-20240084287-A1 SINGLE CELL CELLULAR COMPONENT ENRICHMENT FROM BARCODED SEQUENCING LIBRARIES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-03-14 US disclosed
WO-2004039829-A2 USE OF CPG OLIGONUCLEOTIDES IN THE TREATMENT OF HEPATITIS C VIRUS INFECTION COLEY PHARMACEUTICAL GROUP, LTD. (CA) 2004-05-13 WO disclosed
US-20040067905-A1 Nucleic acid compositions for stimulating immune responses COLEY PHARMACEUTICAL GROUP, INC. 2004-04-08 US disclosed
US-20040053880-A1 Nucleic acid compositions for stimulating immune responses COLEY PHARMACEUTICAL GROUP, INC. 2004-03-18 US disclosed
WO-2004016805-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-02-26 WO disclosed
WO-2004005476-A2 NUCLEIC ACID COMPOSITIONS FOR STIMULATING IMMUNE RESPONSES COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-01-15 WO disclosed