Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866643 | 0.93 | ABL1 (0.51) | ABL1FGFR1KDRFLT1 | |
| SCHEMBL5866631 | 0.93 | ABL1 (0.51) | ABL1FGFR1KDRFLT1 | |
| SCHEMBL5866636 | 0.93 | ABL1 (0.51) | ABL1FGFR1KDRFLT1 | |
| SCHEMBL5866809 | 0.93 | ABL1 (0.51) | ABL1FGFR1KDRFLT1 | |
| SCHEMBL5866728 | 0.93 | ABL1 (0.51) | ABL1FGFR1KDRFLT1 | |
| SCHEMBL3539306 | 0.92 | ABL1 (0.52) | ABL1FGFR1KDRFLT1FLT3 | |
| SCHEMBL3533006 | 0.92 | ABL1 (0.52) | ABL1FGFR1KDRFLT1FLT3 | |
| SCHEMBL3533004 | 0.92 | ABL1 (0.52) | ABL1FGFR1KDRFLT1FLT3 | |
| SCHEMBL3534766 | 0.92 | ABL1 (0.52) | ABL1FGFR1KDRFLT1FLT3 | |
| SCHEMBL3541753 | 0.92 | ABL1 (0.52) | ABL1FGFR1KDRFLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401831-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003004488-A1 | INDAZOLE BENZIMIDAZOLE COMPOUNDS AS TYROSINE AND SERINE/THREONINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |