Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | CCKBR | P32239 | 3/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582611 | 1.00 | PPARA (0.60) | PPARAMAPK1KMT2APPARGCTSS | |
| SCHEMBL6582704 | 0.87 | PPARA (0.59) | PPARAMAPK1KMT2APPARGCTSS | |
| SCHEMBL13198526 | 0.85 | PPARA (0.63) | PPARAKMT2APPARGCTSSKLK7 | |
| SCHEMBL3746299 | 0.84 | PPARA (0.62) | PPARAMAPK1KMT2APPARGCTSS | |
| SCHEMBL2538849 | 0.82 | PPARA (0.60) | PPARAMAPK1KMT2APPARGCTSS | |
| SCHEMBL2538853 | 0.82 | PPARA (0.60) | PPARAMAPK1KMT2APPARGCTSS | |
| SCHEMBL2728641 | 0.80 | PPARA (0.74) | PPARAKMT2APPARGCTSSKLK7 | |
| SCHEMBL2728639 | 0.80 | PPARA (0.74) | PPARAKMT2APPARGCTSSKLK7 | |
| SCHEMBL3893943 | 0.80 | PPARA (0.74) | PPARAKMT2APPARGCTSSKLK7 | |
| SCHEMBL828674 | 0.80 | PPARA (0.90) | PPARAPPARGCTSSKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |